College of Life and Environmental Sciences

The Living Systems Institute (LSI) pioneers transformative science to engineer control of complex biological systems. LSI merges research in biology and medicine with ground-breaking physical sciences technologies and powerful mathematical modelling capabilities. This integrated approach is aimed both at fundamental knowledge and at generating new tools for improving health and treating disease.

The above full time post is available immediately on a fixed term basis for 12 months

The post

Applications are invited for a post-doctoral neuronal cell biologist to work on a research project at the Living Systems Institute to decipher the function of Wnt signalling in synaptogenesis. We are looking to either a Postdoctoral Research Associate or Fellow, depending on the successful candidates’ knowledge, skills and experience.

This is an exciting opportunity to undertake functional studies of Wnt signalling in induced pluripotent stem cell (iPSC)-derived cortical neurons. This project will undertake a functional analysis of beta-catenin dependent and beta-catenin independent Wnt signalling to identify new aspects underlying the cellular pathology of Alzheimer’s, focused on the synaptogenesis to better understand the molecular mechanisms of the disease.

Duties include design and implementation of experiments; interpretation of data; design, generation and use of high-resolution imaging technology; differentiation and analysis of iPSC-derived neurons and cell lines; preparation of data for publication; contribute ideas for new research projects and develop ideas for generating research income; manage own academic research involving small-scale project management and act as a source of information to other members of the group.

What we are looking for

You will have excellent practical experience of working with cell cultures, preferably using iPSC models or neurons, and a good knowledge of cellular models of neurodegenerative disease. The ability to innovate, trouble-shoot technical problems, be meticulous in practical work and in record keeping is also essential. Applicants must hold, or be near completion of, a PhD/DPhil in a relevant area of research and have experience in cellular neuroscience, and molecular cell biology relevant to analysis of neuronal phenotypes.

What we can offer you

  • An exciting pilot study initially for 12months with the possibility of extension
  • Freedom (and the support) to pursue your intellectual interests and to work creatively across disciplines to produce internationally exciting research;
  • Support teams that understand the University wide research and teaching goals and partner with our academics accordingly
  • An Innovation, Impact and Business directorate that works closely with our academics providing specialist support for external engagement and development
  • Our Exeter Academic initiative supporting high performing academics to achieve their potential and develop their career
  • A multitude of staff benefits including sector leading benefits around maternity, adoption and shared parental leave (up to 26 weeks full pay), Paternity leave (up to 6 weeks full pay), and a new Fertility Treatment Policy
  • A beautiful campus set in the heart of stunning Devon
  • The University of Exeter

    We are a member of the prestigious Russell Group of research-intensive universities and in the top 150 universities in the world (Times Higher Education World University Rankings 2019). We combine world-class teaching with world-class research, achieving a Gold rating in the Teaching Excellence Framework Award 2017.

    Our research income in recent years means we’re the fastest growing UK Research University with some of the world’s most influential scientists, and we seek to answer some of the most fundamental issues facing humankind today through this. 98% of our research is of international quality (2014 Research Excellence Framework). We encourage proactive engagement with industry, business and community partners to enhance the impact of research and education and improve the employability of our students. Exeter is one of only a few UK cities to have been designated as a UNESCO Creative City. In 2019, Devon was voted as having the best quality of life of anywhere in England and Wales, making it a popular choice for both work and study.

    Equality, Diversity and Inclusivity at Exeter

    With over 22,000 students and 5,500 staff from 180 different countries we offer a diverse and engaging environment in which to work. We are an equal opportunity employer, a Disability Confident employer and an Athena Swan accredited institution. Since 2019, the university has also signed an Armed Forces Covenant, demonstrating the University’s commitment to supporting the Armed Forces community. Whilst all applicants will be judged on merit alone, we particularly welcome applications from groups currently underrepresented in the workforce.


    We offer some fantastic benefits including:

  • 41 days leave per year
  • options for flexible working
  • numerous discounts at leading retailers
  • onsite gyms on all of our campus’ and a cycle to work scheme
  • sector leading policies around maternity, adoption and shared parental leave (up to 26 weeks full pay), paternity leave (up to six weeks full pay) and a new Fertility Treatment Policy
  • stunning campus environments in Exeter and Cornwall, in the beautiful South West of England
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